Expand your horizons, right next door.

Our downtown location is located at 750 Fifth Avenue. In the heart of San Diego’s historic Gaslamp Quarter, we’re minutes from hotels, Balboa Park, the San Diego Convention Center and Horton Plaza. From the North: Take the 163-South into downtown, continuing onto 10th Ave. Make a right at Market Street, and then a right onto 5th Ave, and Cafe21 will be on your left. From East: Take the 94-West into downtown, continuing onto F St. Make a left on 6th Ave, a right on Market St, and then a right onto 5th Ave. Cafe21 will be on your left.